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OCR: Unfortunately, in the absence of hypos is anosmia, a tumour or a midline defect, with virtually impossible to separate a patien one with isolated gonadotrophin deficiency from vith constitutional delay in growth. Patients e easily trophin primary gonadal failure, however, will diagnosed due to the elevation of gonad eful in the concentrations. The GnRH test may be u n excess in diagnosis of subtle cases of gonadotroph mination primary gonadal failure and in the deter t with of endocrine onset of puberty in a patien of physical constitutional delay who is on the verge development.